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Lancet 401(10382):10911102 Schaudig K, Wang X, Bouchard C, Hirschberg AL, Cano A, Shapiro CMM et al (2024) Efficacy and safety of fezolinetant for moderate-severe vasomotor symptoms associated with menopause in individuals unsuitable for hormone therapy: phase 3b randomised controlled trial

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The NRTI 3-deoxy-3-fluorothymidine ( alovudine or FLT), known for its high toxicity, can cause DNA fragmentation and induce apoptosis (Sundseth et al., 1996)